GLP-1 receptor agonists like semaglutide and tirzepatide have taken the spotlight for weight loss, with studies showing 15-25% body weight reduction (e.g., 2025 Endocrinology review). But what about other peptides? Beyond GLP-1s, several lesser-known peptides offer powerful benefits for fat loss, metabolism, and muscle preservation, making them ideal for those seeking sustainable weight management. At PrimeBody, we’re here to guide you through these options with personalized, doctor-led care. Let’s explore four peptides that can help you achieve your weight loss goals, their mechanisms, and key considerations.

1. Tesamorelin: Targeting Visceral Fat

Tesamorelin, a growth hormone-releasing hormone (GHRH) analog, stimulates the pituitary gland to produce more growth hormone, which enhances fat metabolism, particularly in the abdominal area.

• How It Works: Increases growth hormone levels, promoting lipolysis (fat breakdown) and reducing visceral fat by 15-20%, per a 2025 Healthy Outlook study.
• Benefits: Reduces stubborn belly fat, improves metabolic health, and supports lean muscle mass, which boosts calorie burning.
• Best For: Individuals with central obesity or hormone-related weight gain.
• Considerations: Administered via daily subcutaneous injections. Side effects are minimal but may include mild joint pain or injection-site reactions. Not FDA-approved for weight loss but used off-label with medical supervision.

2. AOD-9604: The Fat-Burning Fragment

AOD-9604 is a synthetic fragment of human growth hormone (hGH) designed specifically to accelerate fat metabolism without impacting blood sugar or muscle growth.

• How It Works: Mimics hGH’s fat-burning properties, enhancing lipolysis and inhibiting fat storage, leading to 5-10% weight loss in clinical settings (2025 Genesis Integrative Med data).
• Benefits: Targets fat loss in areas like the thighs and hips, with a low side effect profile, making it ideal for targeted weight reduction.
• Best For: Those seeking fat loss without appetite suppression or complex metabolic needs.
• Considerations: Not FDA-approved for weight loss but considered safe under medical guidance. Typically injected daily; results are enhanced with exercise.

3. CJC-1295/Ipamorelin: The Metabolic Booster Duo

This peptide combination pairs CJC-1295 (a GHRH analog) with Ipamorelin (a ghrelin mimetic) to stimulate natural growth hormone production, boosting metabolism and energy.

• How It Works: Increases growth hormone secretion, which enhances fat metabolism and muscle growth, leading to 5-15% fat reduction over time, per 2025 BodySpec research.
• Benefits: Improves energy, supports muscle preservation during weight loss, and enhances sleep, which aids recovery and hormone balance.
• Best For: Aging adults with slowed metabolism or those seeking anti-aging benefits alongside fat loss.
• Considerations: Administered via nightly injections. Side effects are rare but may include mild headaches. Requires consistent use for optimal results.

4. BPC-157: The Recovery and Gut Health Ally

BPC-157, a synthetic peptide derived from a gastric protein, promotes tissue repair and gut health, indirectly supporting weight loss by improving overall wellness.

• How It Works: Enhances gut health and reduces inflammation, which can improve nutrient absorption and metabolic efficiency, per 2025 Medical News Today insights. May support 5-10% weight loss when combined with diet and exercise.
• Benefits: Reduces inflammation-related weight gain, speeds workout recovery, and supports digestive health, which can curb overeating.
• Best For: Those with inflammation-driven weight gain or digestive issues impacting metabolism.
• Considerations: Not FDA-approved for weight loss; typically injected or taken orally. Minimal side effects but requires medical oversight for dosing.

Why Look Beyond GLP-1s?

While GLP-1 agonists like semaglutide excel at appetite suppression and blood sugar control, peptides like tesamorelin, AOD-9604, CJC-1295/Ipamorelin, and BPC-157 target complementary pathways—fat metabolism, growth hormone production, and inflammation reduction. These options are ideal for those who may not respond to GLP-1s, need targeted fat loss, or want to combine therapies for enhanced results. A 2025 Journal of Obesity study notes that combining peptides with lifestyle changes can improve long-term weight loss success by 30% compared to diet alone.

Key Considerations for Peptide Use

Peptides are not one-size-fits-all. They work best with a healthy diet (e.g., 0.8-1g protein per pound of body weight), regular exercise, and medical supervision. Potential side effects include injection-site reactions or mild fatigue, which are manageable with proper dosing. Since some peptides (e.g., AOD-9604, BPC-157) are not FDA-approved for weight loss, professional guidance is crucial to ensure safety and efficacy. Self-administration without oversight can lead to risks like improper dosing or interactions.

Trust PrimeBody for Expert Guidance on Peptides

Navigating the world of peptides for weight loss can be complex, but PrimeBody makes it seamless with our expert-led telehealth platform. Our licensed medical team provides personalized consultations to match you with the right peptides—whether it’s tesamorelin for belly fat or CJC-1295/Ipamorelin for metabolism. With tailored plans, regular monitoring, and discreet home delivery, we ensure safe, effective weight loss. Ready to transform your body and health? Visit primebody.com to schedule your consultation today and take the first step toward sustainable weight loss!