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Hormone Therapy and Alzheimer's Disease

Hormone Therapy and Alzheimer's Disease

A recent meta-analysis suggests that hormone replacement therapy may offer protection against Alzheimer's disease and dementia, but it appears to be most effective when initiated during the 40s and 50s when menopausal symptoms typically begin.

The degree of protection observed varies depending on the type of hormone therapy used, as highlighted in the report.

Menopause typically begins at an average age of 51, as defined by a woman's lack of menstruation for 12 consecutive months. However, the transition into this phase can naturally occur between the ages of 40 and 58, according to The Menopause Society. Symptoms like hot flashes, night sweats, sleep disturbances, changes in libido, heart palpitations, and vaginal discomfort can manifest years before menopause, during the perimenopausal phase.


The Study

The study in question, published in the journal Frontiers in Aging Neuroscience, sought to provide a comprehensive evaluation of the effects of menopausal hormone therapy on the risk of Alzheimer's disease and dementia. The researchers conducted a systematic review and meta-analysis, examining both randomized controlled trials (RCTs) and observational reports to consolidate the available evidence.


Key Findings

1 - Randomized Controlled Trials (RCT)

The analysis of RCTs involving postmenopausal women aged 65 and older revealed an increased risk of dementia with hormone therapy compared to a placebo group.

The overall relative risk (RR) for dementia was 1.38, with a 95% confidence interval (CI) of 1.16–1.64. This suggests that hormone therapy is associated with a higher risk of dementia in this age group.

Notably, this increased risk was primarily driven by estrogen-plus-progestogen therapy (EPT), with an RR of 1.64, whereas estrogen-only therapy (ET) did not exhibit significant effects on dementia risk.

2 - Observational Studies

In contrast, observational studies indicated a reduced risk of AD and all-cause dementia with hormone therapy use.

The RR for AD risk was 0.78, with a 95% CI of 0.64–0.95, and for all-cause dementia, the RR was 0.81, with a 95% CI of 0.70–0.94.

Protective effects were noted specifically with ET, with an RR of 0.86, while EPT did not show the same benefits.

3 - Stratified Analysis

Further analysis suggested that midlife ET was associated with a 32% reduced risk of dementia (RR = 0.685), with a 95% CI of 0.513–0.915, while midlife EPT had non-significant reductions.

Late-life HT use was linked to an increased risk, although not statistically significant.



These intriguing findings raise several questions and highlight the need for continued research in this area. The contrasting results between RCTs and observational studies emphasize the complexity of the relationship between hormone therapy and AD risk. The study's results support the idea that midlife estrogen therapy, particularly ET, may play a protective role in reducing the risk of dementia. This offers a compelling direction for future research. Your Partner in Hormone Balance

In light of this research, individuals facing hormone imbalances, especially those transitioning through menopause, may have questions about the role of hormone therapy. This is where steps in as a valuable resource. offers a range of solutions and expertise to help patients address hormone imbalances effectively.

Hormone Replacement Therapy (HRT): provides access to qualified healthcare professionals who can guide patients through hormone replacement therapy tailored to their specific needs. The site offers comprehensive information about HRT options, benefits, and potential risks, empowering patients to make informed decisions about their health.

Education and Support: is not just a provider of hormone therapy but also a platform for education and support. Patients can access a wealth of information about hormone imbalance, menopause, and the latest research findings, allowing them to stay informed about their health.

Telemedicine: offers telemedicine services, making it convenient for patients to connect with healthcare providers from the comfort of their homes. This accessibility is especially beneficial for those seeking hormone therapy consultations and follow-up care.

Visit to get started.

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